Clindamycin HCL Capsules 300mg

Wholesale Price: /$50.00

Case size 100 count

Cronus Pharma
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Description

Clindamycin Hydrochloride Capsules, USP contain clindamycin hydrochloride which is the hydrated salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced antibiotic produced by Streptomyces lincolnensis var. lincolnensis.

Clindamycin Hydrochloride Capsules, USP (For Use in Dogs Only): 25 mg Capsule, each yellow and colorless capsule contains clindamycin hydrochloride equivalent to 25 mg of clindamycin. 75 mg Capsule, each green and colorless capsule contains clindamycin hydrochloride equivalent to 75 mg of clindamycin. 150 mg Capsule, each blue and colorless capsule contains clindamycin hydrochloride equivalent to  150 mg of clindamycin. 300 mg Capsule, each turquoise and colorless capsule contains clindamycin hydrochloride equivalent to 300 mg of clindamycin.

CLINICAL PHARMACOLOGY

Absorption Clindamycin hydrochloride is rapidly absorbed from the canine gastrointestinal tract.

Dog Serum Levels Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every 12 hours. This same study revealed that average peak serum concentrations of clindamycin occur 1 hour and 15 minutes after oral dosing. The elimination half -life for clindamycin in dog serum was approximately 5 hours. There was no bioactivity accumulation after a regimen of multiple oral doses in healthy dogs. Clindamycin Serum Concentrations 2.5 mg/lb (5.5 mg/kg) After B.I.D. Oral Dose of Clindamycin Hydrochloride Capsules to Dogs clindamycin   1 The correlation between the in vitro susceptibility data and clinical response has not been determined. 2 Soft Tissue/Wound: includes samples labeled wound, abscess, aspirate, exudates, draining tract, lesion, and mass. 3 Osteomyelitis/Bone: includes samples labeled bone, fracture, joint, tendon 4 No range, all isolates yielded the same value 5 Dermal/Skin: includes labeled skin, skin swab, biopsy, incision, lip

INDICATIONS

Clindamycin Hydrochloride Capsules, USP (for use in dogs only) are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below:

Dogs: Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.
 
Product Sheet

CASE SIZE

100 count

COMMON BRAND NAME(S)

Clindamycin HCL

FOR USE WITH

Dogs

ADMINISTRATION FORM

Oral

USAGE

Treatment of infections

LIFESTAGE

Puppy, Adult, Senior

PRODUCT FORM

Capsule

STRENGTH

300mg

HEALTH CONDITION

Infection

DRUG TYPE

Antibiotics

Clindamycin
CONTRAINDICATIONS Clindamycin Hydrochloride Capsules, USP are contraindicated in animals with a history of hypersensitivity to preparations containing clindamycin or lincomycin. Because of potential adverse gastrointestinal effects, do not administer to rabbits, hamsters, guinea pigs, horses, chinchillas or ruminating animals. WARNINGS Keep out of reach of children. Not for human use. PRECAUTIONS During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed. The use of Clindamycin Hydrochloride Capsules, USP occasionally results in overgrowth of non-susceptible organisms such as clostridia and yeasts. Therefore, the administration of Clindamycin Hydrochloride Capsules should be avoided in those species sensitive to the gastrointestinal effects of clindamycin (see CONTRAINDICATIONS). Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation. Patients with very severe renal disease and/or very severe hepatic disease accompanied by severe metabolic aberrations should be dosed with caution, and serum clindamycin levels monitored during high-dose therapy. Clindamycin hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, Clindamycin Hydrochloride Capsules, USP should be used with caution in animals receiving such agents. Safety in gestating bitches and queens or breeding male dogs has not been established. ADVERSE REACTIONS Side effects occasionally observed in either clinical trials or during clinical use were vomiting and diarrhea. To report a suspected adverse reaction call 1-844-227-6687 (1-844-2-CRONUS) DOSAGE AND ADMINISTRATION Dogs: Infected Wounds, Abscesses, and Dental Infections Oral: 2.5-15.0 mg/lb body weight every 12 hours. Duration: Treatment with Clindamycin Hydrochloride capsules, USP may be continued up to a maximum of 28 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three or four days if no response to therapy is seen. Dosage Schedule Capsules Clindamycin Hydrochloride Capsules, USP 25 mg, administer 1-6 capsules every 12 hours for each 10 pounds of body weight. Clindamycin Hydrochloride Capsules, USP 75 mg, administer 1 -6 capsules every 12 hours for each 30 pounds of body weight. Clindamycin Hydrochloride Capsules, USP 150 mg, administer 1-6 capsules every 12 hours for each 60 pounds of body weight. Clindamycin Hydrochloride Capsules, USP 300 mg, administer 1-6 capsules every 12 hours for each 120 pounds of body weight. Dogs: Osteomyelitis Oral: 5.0-15.0 mg/lb body weight every 12 hours. Duration: Treatment with Clindamycin Hydrochloride Capsules is recommended for a minimum of 28 days. Treatment should not be continued for longer than 28 days if no response to therapy is seen. Dosage Schedule: Capsules Clindamycin Hydrochloride Capsules, USP 25 mg, administer 2-6 capsules every 12 hours for each 10 pounds of body weight. Clindamycin Hydrochloride Capsules, USP 75 mg, administer 2 -6 capsules every 12 hours for each 30 pounds of body weight. Clindamycin Hydrochloride Capsules, USP 150 mg, administer 2-6 capsules every 12 hours for each 60 pounds of body weight. Clindamycin Hydrochloride Capsules, USP 300 mg, administer 2-6 capsules every 12 hours for each 120 pounds of body weight. STORAGE Store at controlled room temperature 68° to 77°F (20° to 25°C). How Supplied Clindamycin Hydrochloride Capsules are available as: 25 mg -  bottles of 200 75 mg - bottles of 200 150 mg - bottles of 100 and 500 300 mg - bottles of 100 Nam nunc purus, mollis sed orci sit amet, pulvinar pretium mi. Nunc eu mi mi. Donec mi massa, mollis eu mattis sit amet, consequat in lorem. 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